Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …

Self-help by means of dietary interventions can help in management of various disorders
including rheumatoid arthritis (RA), a debilitating autoimmune disease. Dietary interventions …

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality
rates among rheumatic diseases. We perform a large genome-wide association study …

Systemic lupus erythematosus (SLE or lupus) is a heterogeneous autoimmune disease
characterized by the involvement of multiple organs and the production of antinuclear …

The last decade has seen a dramatic technological revolution. The characterisation of the
majority of the common variations in our genetic code in 2003 precipitated the discovery of …

Spondyloarthritides (SpA) include inflammatory joint diseases with various clinical
phenotypes that may also include the axial skeleton and/or entheses. SpA include psoriatic …

It remains challenging to translate the findings from genome-wide association studies
(GWAS) of autoimmune diseases (AIDs) into interventional targets, presumably due to the …

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints.
Susceptibility and severity of this disease are influenced by nongenetic factors, such as …

Systemic sclerosis (SSc) is a clinically heterogeneous connective tissue disorder of complex
etiology. The development of large-scale genetic studies, such as genome-wide association …

Purpose of Review DNA methylation has emerged as an important contributing factor in the
pathogenesis of systemic lupus erythematosus (SLE). Here, we describe the DNA …