Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public …

Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade

P Dandona, S Dhindsa, H Ghanim… - Journal of human …, 2007 - nature.com
Abstract Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines
and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth …

Oxidized low-density lipoprotein and atherosclerosis implications in antioxidant therapy

S Mitra, A Deshmukh, R Sachdeva, J Lu… - The American journal of …, 2011 - Elsevier
Abstract Low-density lipoprotein (LDL)-cholesterol is important for cellular function, but in
high concentrations, it can lead to atheroma formation. Over the past several decades, it has …

[PDF][PDF] Angiotensin II and vascular inflammation

ZJ Cheng, H Vapaatalo, E Mervaala - Med Sci Monit, 2005 - researchgate.net
Vascular inflammation is involved in the initiation and progression of atherosclerosis, and is
also present in hypertension-and diabetes-induced vascular complications. Angiotensin II …

Modulation of the inflammatory response in cardiovascular disease

DN Granger, T Vowinkel, T Petnehazy - Hypertension, 2004 - Am Heart Assoc
There is a growing body of evidence that inflammation might play an important role in the
initiation and progression of cardiovascular diseases (CVDs). The designation of CVD as a …

Pathophysiological association of endothelial dysfunction with fatal outcome in COVID-19

T Maruhashi, Y Higashi - International Journal of Molecular Sciences, 2021 - mdpi.com
The outbreak of coronavirus disease 2019 (COVID-19) caused by the betacoronavirus
SARS-CoV-2 is now a worldwide challenge for healthcare systems. Although the leading …

Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7)

I Kucharewicz, R Pawlak, T Matys, D Pawlak… - …, 2002 - Am Heart Assoc
It is well established that renin-angiotensin system blockers exert NO/prostacyclin-
dependent antithrombotic effects. Because some beneficial effects of these drugs are …

Pharmacological modulation of platelet function in hypertension

AD Blann, S Nadar, GYH Lip - Hypertension, 2003 - Am Heart Assoc
Platelets exert a considerable influence on human morbidity and mortality. The rationale for
their study in hypertension follows the observation that the major consequences of …

Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition

A Schäfer, D Fraccarollo, S Hildemann… - Thrombosis and …, 2003 - thieme-connect.com
An increased risk of thrombembolic events in congestive heart failure (CHF) has been
attributed to a hypercoagulable state including vascular endothelial dysfunction and platelet …

Old antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists

H Abali, IH Güllü, H Engin, IC Haznedaroğlu… - Medical hypotheses, 2002 - Elsevier
Angiogenesis, cellular growth and invasion of a cancer cell are attractive targets for new
treatment strategies of malignancies in recent years. The evidences are accumulating that …