Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …

Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal
roles in many aspects of the immune response, including immune cell development and …

A complete chart of cis-regulatory elements and their dynamic activity is necessary to
understand the transcriptional basis of differentiation and function of an organ system. We …

The mononuclear phagocyte system (MPS) has historically been categorized into
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …

It is well understood that antigen-presenting cells (APCs) within tumors typically do not
maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse …

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and
maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2, 3-dioxygenase 1 …