Since the discovery of cell-penetrating peptides (CPP) in the 1980s, they have played a
unique role in various fields owing to their excellent and unique cell membrane penetration …

HIV-derived TAT peptide, with a high penetration rate into cells and its nonimmunogenic and
minimally toxic nature, is an attractive tool for enhancing the biodistribution of drugs and …

Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab
family. Besides possible recycling routes to the plasma membrane and various organelles …

Cell-penetrating peptides (CPPs) are short (< 30 amino acids), generally cationic, peptides
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …

Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules.
The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based …

We here report assembling synergistic peptide-drug conjugates (asPDCs) with the
therapeutic activity arising from both peptide and chemodrug moieties for treatment of …

Peptides have gained more and more interest as therapeutics for different fields of medical
indications. Built up via a peptide bond from naturally occurring amino acids they stand out …

Antimicrobial peptides (AMPs) preferentially permeate prokaryotic membranes via
electrostatic binding and membrane remodeling. Such action is drastically suppressed by …

Objectives Biofilms are structured aggregates of bacteria embedded in a self-produced
matrix that develop in diverse ecological niches. Pathogenic bacteria can form biofilms on …

Cell-penetrating peptides cross cell membranes through various parallel internalization
pathways. Herein, we analyze the role of the negatively charged lipid phosphatidylinositol-4 …