Anatomy of four human Argonaute proteins

K Nakanishi - Nucleic acids research, 2022 - academic.oup.com
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …

Argonaute proteins: functional insights and emerging roles

G Meister - Nature Reviews Genetics, 2013 - nature.com
Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …

Circular RNAs are a large class of animal RNAs with regulatory potency

S Memczak, M Jens, A Elefsinioti, F Torti, J Krueger… - Nature, 2013 - nature.com
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human …

The imprinted H19 lncRNA antagonizes let-7 microRNAs

AN Kallen, XB Zhou, J Xu, C Qiao, J Ma, L Yan, L Lu… - Molecular cell, 2013 - cell.com
Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19
long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer …

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

AE Pasquinelli - Nature Reviews Genetics, 2012 - nature.com
MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013 - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

FMRP targets distinct mRNA sequence elements to regulate protein expression

M Ascano, N Mukherjee, P Bandaru, JB Miller… - Nature, 2012 - nature.com
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-
orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a …

Regulation of mRNA translation and stability by microRNAs

MR Fabian, N Sonenberg… - Annual review of …, 2010 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

[HTML][HTML] Origins and mechanisms of miRNAs and siRNAs

RW Carthew, EJ Sontheimer - Cell, 2009 - cell.com
Over the last decade,∼ 20–30 nucleotide RNA molecules have emerged as critical
regulators in the expression and function of eukaryotic genomes. Two primary categories of …

[HTML][HTML] Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

M Hafner, M Landthaler, L Burger, M Khorshid… - Cell, 2010 - cell.com
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of
RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes …