Human monocytes are divided in three major populations; classical (CD14+ CD16−), non-
classical (CD14dimCD16+), and intermediate (CD14+ CD16+). Each of these subsets is …

Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

Caloric restriction is known to improve inflammatory and autoimmune diseases. However,
the mechanisms by which reduced caloric intake modulates inflammation are poorly …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Childhood obesity is a leading public health problem worldwide, as it is increasingly
prevalent and therefore responsible for serious obesity-related comorbidities, not only in …

Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …

Immune cells were traditionally considered as major pro-inflammatory contributors. Recent
advances in molecular immunology prove that immune cell lineages are composed of …

Obesity is associated with infiltration of macrophages into adipose tissue (AT), contributing
to insulin resistance and diabetes. However, relatively little is known regarding the origin of …

The gut microbiota is recognized to have an important role in energy storage and the
subsequent development of obesity. To date, bariatric surgery (indicated for severe obesity) …

Obesity is associated with an activated macrophage phenotype in multiple tissues that
contributes to tissue inflammation and metabolic disease. To evaluate the mechanisms by …