HMGB1 in health and disease

R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

HMGB proteins: interactions with DNA and chromatin

M Štros - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2010 - Elsevier
HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …

[PDF][PDF] High‐mobility group box‐1 and liver disease

H Gaskell, X Ge, N Nieto - Hepatology communications, 2018 - Wiley Online Library
High‐mobility group box‐1 (HMGB1) is a ubiquitous protein. While initially thought to be
simply an architectural protein due to its DNA‐binding ability, evidence from the last decade …

HMGB1 protein: a therapeutic target inside and outside the cell

I Ugrinova, E Pasheva - Advances in protein chemistry and structural …, 2017 - Elsevier
High-mobility group box 1 protein (HMGB1) is a nonhistone chromosomal protein
discovered more than 30 years ago. It is an abundant nuclear protein that has a dual …

Cisplatin dependent secretion of immunomodulatory high mobility group box 1 (HMGB1) protein from lung cancer cells

KP Gillespie, R Pirnie, C Mesaros, IA Blair - Biomolecules, 2023 - mdpi.com
High mobility group box 1 (HMGB1) is secreted from activated immune cells, necrotic cells,
and certain cancers. Previous studies have reported that different patterns of post …

Poly (ADP-ribosyl) ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis

K Davis, S Banerjee, A Friggeri, C Bell, E Abraham… - Molecular …, 2012 - Springer
Phagocytosis of apoptotic cells by macrophages, known as efferocytosis, is a critical process
in the resolution of inflammation. High mobility group box 1 (HMGB1) protein was first …

Role of glycated high mobility group box-1 in gastric cancer

S Kishi, Y Nishiguchi, K Honoki, S Mori… - International Journal of …, 2021 - mdpi.com
Advanced glycation end products (AGEs) are produced in response to a high-glucose
environment and oxidative stress and exacerbate various diseases. N ε-(Carboxymethyl) …

Influence of DNA Type on the Physicochemical and Biological Properties of Polyplexes Based on Star Polymers Bearing Different Amino Functionalities

E Haladjova, S Panseri, M Montesi, A Rossi… - Polymers, 2023 - mdpi.com
The interactions of two star polymers based on poly (2-(dimethylamino) ethyl methacrylate)
with different types of nucleic acids are investigated. The star polymers differ only in their …

HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail

D Topalova, I Ugrinova, IG Pashev… - The international journal of …, 2008 - Elsevier
The high mobility group box (HMGB) 1 protein is a very abundant and conserved protein that
is implicated in many key cellular events but its functions within the nucleus remain elusive …

Nucleosome binding properties and Co-remodeling activities of native and in vivo acetylated HMGB-1 and HMGB-2 proteins

I Ugrinova, IG Pashev, EA Pasheva - Biochemistry, 2009 - ACS Publications
The participation of HMGB-1 and-2 proteins in chromatin remodeling is investigated. Here,
the ability of these proteins and their posttranslationally acetylated forms to affect SWI/SNF …