Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

[HTML][HTML] Mechanisms of noise-induced tinnitus: insights from cellular studies

SE Shore, C Wu - Neuron, 2019 - cell.com
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the
population and is the top-reported disability for soldiers after combat. Noise overexposure is …

Macrophage depletion attenuates degeneration of spiral ganglion neurons in kanamycin-induced unilateral hearing loss model

MD Shimada, M Noda, R Koshu, Y Takaso… - Scientific Reports, 2023 - nature.com
Pathological conditions in cochlea, such as ototoxicity, acoustic trauma, and age-related
cochlear degeneration, induce cell death in the organ of Corti and degeneration of the spiral …

Glutamatergic projections to the cochlear nucleus are redistributed in tinnitus

AN Heeringa, C Wu, C Chung, M West, D Martel… - Neuroscience, 2018 - Elsevier
Tinnitus alters auditory–somatosensory plasticity in the cochlear nucleus (CN).
Correspondingly, bimodal auditory–somatosensory stimulation treatment attenuates tinnitus …

Vulnerability to chronic stress and the phenotypic heterogeneity of presbycusis with subjective tinnitus

J Ruan, X Hu, Y Liu, Z Han, Q Ruan - Frontiers in Neuroscience, 2022 - frontiersin.org
Age-related functional reserve decline and vulnerability of multiple physiological systems
and organs, as well as at the cellular and molecular levels, result in different frailty …

Piccolo promotes vesicle replenishment at a fast central auditory synapse

T Butola, C Wichmann, T Moser - Frontiers in synaptic neuroscience, 2017 - frontiersin.org
Piccolo and Bassoon are the two largest cytomatrix of the active zone (CAZ) proteins
involved in scaffolding and regulating neurotransmitter release at presynaptic active zones …

Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus

T Kurioka, MY Lee, AN Heeringa, LA Beyer… - Neuroscience, 2016 - Elsevier
In experimental animal models of auditory hair cell (HC) loss, insults such as noise or
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …

[HTML][HTML] Effects of Castanopsis echinocarpa on Sensorineural Hearing Loss via Neuronal Gene Regulation

I Rodriguez, YH Nam, SW Shin, GJ Seo, NW Kim… - Nutrients, 2024 - mdpi.com
Sensorineural hearing loss (SNHL), characterized by damage to the inner ear or auditory
nerve, is a prevalent auditory disorder. This study explores the potential of Castanopsis …

[HTML][HTML] Gαi proteins are indispensable for hearing

S Beer-Hammer, SC Lee, SA Mauriac, V Leiss… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: From invertebrates to mammals, Gα i proteins act together with their
common binding partner Gpsm2 to govern cell polarization and planar organization in …

Onset-offset cortical auditory evoked potential amplitude differences indicate auditory cortical hyperactivity and reduced inhibition in people with tinnitus

K Morse, KR Vander Werff - Clinical Neurophysiology, 2023 - Elsevier
Objective The current study investigates evidence of hypothesized reduced central inhibition
and/or increased excitation in individuals with tinnitus by evaluating cortical auditory onset …