Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Melatonin is a ubiquitous hormone found in various organisms and highly affects the
function of immune cells. In this review, we summarize the current understanding of the …

This review summarizes the numerous observations published in recent years which have
shown that one of the most significant of melatonin's pleiotropic effects is the regulation of …

The neurohormone N-acetyl-5-methoxytryptamine, better known as melatonin, is a
tryptophan derivative with a wide range of biological effects that is present in many …

After the successful discovery of the melatonin molecule by Aaron B Lerner et al at Yale
University in 1958, melatonin and the pineal gland, a tiny endocrine gland situated at the …

We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB)
induces the synthesis of melatonin by macrophages and that macrophage-synthesized …

It is known that down-regulation of the immune response may be associated with the
progenesis, development and prognosis of cancer or infectious diseases. Up-regulating the …