Should Trypanosoma cruzi be called" cruzi" complex? A review of the parasite diversity and the potential of selecting population after in vitro culturing and mice …

R Devera, O Fernandes, JR Coura - Memórias do Instituto Oswaldo …, 2003 - SciELO Brasil
Morpho-biological diversity of Trypanosoma cruzi has been known since Chagas' first works
in 1909. Several further studies confirmed the morphological differences among the parasite …

Approaches to protozoan drug discovery: phenotypic screening: miniperspectives series on phenotypic screening for antiinfective targets

ML Sykes, VM Avery - Journal of medicinal chemistry, 2013 - ACS Publications
Determining the activity of a compound and the potential impact on a diseased state is
frequently undertaken using phenotypic or target-based approaches. Phenotypic screens …

Metabolic Alteration of Trypanosoma cruzi during Differentiation of Epimastigote to Trypomastigote Forms

SG De-Simone, SC Bourguignon, PS Gonçalves… - Pathogens, 2022 - mdpi.com
Intracellular parasites such as Trypanosoma cruzi need to acquire valuable carbon sources
from the host cell to replicate. Here, we investigated the energetic metabolism of T. cruzi …

Trypanosoma cruzi: A review of biological and methodological factors in Mexican strains

JA De Fuentes-Vicente, DG Vidal-López… - Acta tropica, 2019 - Elsevier
Trypanosoma cruzi, responsible for Chagas disease, is a serious public health problem in
Latin America with eight million people infected in the world. Clinical manifestations …

Biology of the schistosome lung-stage schistosomulum

GN Gobert, M CHAI, DP McManus - Parasitology, 2007 - cambridge.org
Past and more recent research has examined the ultrastructure, metabolism, cell biology,
genomics and post-genomics of schistosome schistosomula. These areas are considered …

Calpains: potential targets for alternative chemotherapeutic intervention against human pathogenic trypanosomatids

M H. Branquinha, F A. Marinho… - Current medicinal …, 2013 - benthamdirect.com
The treatment for both leishmaniasis and trypanosomiasis, which are severe human
infections caused by trypanosomatids belonging to Leishmania and Trypanosoma genera …

[HTML][HTML] Workflow of Lotmaria passim isolation: Experimental infection with a low-passage strain causes higher honeybee mortality rates than the PRA-403 reference …

M Buendía-Abad, M Higes, R Martín-Hernández… - International Journal for …, 2021 - Elsevier
The impact of trypanosomatid parasites on honeybee health may represent a major threat to
bee colonies worldwide. However, few axenic isolates have been generated to date and …

Transcriptional Studies on Trypanosoma cruzi – Host Cell Interactions: A Complex Puzzle of Variables

MG Libisch, N Rego, C Robello - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Chagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight
million people in the world. T. cruzi is a complex taxon represented by different strains with …

Arrested growth of Trypanosoma cruzi by the calpain inhibitor MDL28170 and detection of calpain homologues in epimastigote forms

LS Sangenito, V Ennes-Vidal, FA Marinho… - Parasitology, 2009 - cambridge.org
In this paper, we aimed to explore the effects of the calpain inhibitor III (MDL28170) and to
detect calpain-like molecules (CALPs) in epimastigote forms of Trypanosoma cruzi isolate …

Mitochondrial gene expression is responsive to starvation stress and developmental transition in Trypanosoma cruzi

AK Shaw, MC Kalem, SL Zimmer - Msphere, 2016 - Am Soc Microbiol
Trypanosoma cruzi parasites causing Chagas disease are passed between mammals by
the triatomine bug vector. Within the insect, T. cruzi epimastigote-stage cells replicate and …