Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Due to the importance of the Gibbs free energy of solvation in understanding many
physicochemical phenomena, including lipophilicity, phase equilibria and liquid-phase …

Abstract Background/Objectives: Quantitative Structure–Activity Relationship
(QSAR)/Quantitative Structure–Property Relationship (QSPR) model is based on changes in …

Quorum sensing (QS) plays an important role in the biofilm formation, production of
virulence factors and stress responses in Vibrio harveyi. Therefore, interrupting QS is a …

The ability to identify the site of a protein that can bind with high affinity to small, drug-like
compounds has been an important goal in drug design. Sirtuin 2 (SIRT2), histone …

Nuclear factor kappa B (NF-κB) is a transcription factor, plays a crucial role in the regulation
of various physiological processes such as differentiation, cell proliferation and apoptosis. It …

Abstract New coumarins, namely (E)-N′-(2-methylbenzylidene)-2-((2-oxo-2H-chromen-4-
yl) oxy) acetohydrazide 4, N-(4-oxo-2-(o-tolyl) thiazolidin-3-yl)-2-((2-oxo-2H-chromen-4-yl) …

In the present study, quantitative structure–activity-relationship (QSAR) study on a group of
sulfonamide Schiff-base inhibitors of Carbonic Anhydrase (CA) enzyme has been carried …

QSAR studies on a series of 2-benzoxazolyl hydrazone derivatives against various cancer
cell lines were carried out to interpret the physicochemical properties responsible for the …

Inhibition activities of a series of 4-substituted-2, 3, 5, 6-tetrafluorobenzenesulfonamides
against the human carbonic anhydrase II (HCAII) enzyme have been explored by employing …