Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

Learning and memory require coordinated structural and functional plasticity at neuronal
glutamatergic synapses located on dendritic spines. Here, we investigated how the …

Intracellular Ca 2+ signals are temporally controlled and spatially restricted. Signaling
occurs adjacent to sites of Ca 2+ entry and/or release, where Ca 2+-dependent effectors and …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …

Cells regulate gene expression in response to salient external stimuli. In neurons,
depolarization leads to the expression of inducible transcription factors (ITFs) that direct …

The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …

In mammalian brain neurons, membrane depolarization leads to voltage-gated Ca2+
channel-mediated Ca2+ influx that triggers diverse cellular responses, including gene …

The expression of several hippocampal genes implicated in learning and memory
processes requires that Ca2+ signals generated in dendritic spines, dendrites, or the soma …