Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Pulmonary surfactant has two crucial roles in respiratory function; first, as a biophysical entity
it reduces surface tension at the air water interface, facilitating gas exchange and alveolar …

The type 2 immune response controls helminth infection and maintains tissue homeostasis
but can lead to allergy and fibrosis if not adequately regulated. We have discovered local …

Pulmonary surfactant (PS) constitutes the first line of host defense in the deep lung. Because
of its high content of phospholipids and surfactant specific proteins, the interaction of inhaled …

C1q and mannose binding lectin, members of the “defense collagen” family, are pattern
recognition molecules that can trigger rapid enhanced phagocytosis resulting in efficient …

Pulmonary collectins, hydrophilic surfactant proteins A and D (SP‐A and SP‐D), have been
implicated in the regulation of pulmonary host defence and inflammation. SP‐A and SP‐D …

The lung is repeatedly exposed to inhaled particles and pathogens that are cleared by the
actions of a multi-component innate host defense system. The pulmonary collectins …

The pulmonary innate immune system responds to various airborne microbes. Although its
specificity is broad and based on the recognition of pathogen-associated molecular patterns …

Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins
that induce curvature of the Golgi membrane are predicted to be required, by analogy to …

Soluble defense collagens form a group of secreted proteins that are primarily involved in
host defense. All defense collagens contain a globular recognition domain contiguous to a …