UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Major advances in the characterization of uridine diphosphate (UDP)-
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …

The purpose of the present study was to determine the absolute protein expression levels of
multiple drug-metabolizing enzymes and transporters in 17 human liver biopsies, and to …

Propofol is an intravenous short‐acting anesthetic widely used to induce and maintain
general anesthesia and to provide procedural sedation. The potential for propofol …

The measurement of the effect of new chemical entities on human UDP-
glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an …

Glucuronidation is an important metabolic pathway for many small endogenous and
exogenous lipophilic compounds, including bilirubin, steroid hormones, bile acids …

The purpose of this study was to generate, by real-time PCR, a quantitative expression level
profile of the 19 human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A and 2B …

The human uridine diphospho (UDP)-glucuronosyltransferase (UGT) superfamily comprises
enzymes responsible for a major biotransformation phase II pathway: the glucuronidation …

Metabolic disposition of drugs and other xenobiotics includes glucuronidation reactions that
are catalyzed by the uridine diphosphate glucuronosyltransferases (UGTs). The most …

During the process of drug discovery, the pharmaceutical industry is faced with numerous
challenges. One challenge is the successful prediction of the major routes of human …