[HTML][HTML] Innate immune evasion by human respiratory RNA viruses

M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Decoding type I and III interferon signalling during viral infection

EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

RE Randall, S Goodbourn - Journal of general virology, 2008 - microbiologyresearch.org
The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years

PL Collins, JA Melero - Virus research, 2011 - Elsevier
Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …

Bovine respiratory syncytial virus infection

JF Valarcher, G Taylor - Veterinary research, 2007 - hal.science
Bovine respiratory syncytial virus (BRSV) belongs to the pneumovirus genus within the
family Paramyxoviridae and is a major cause of respiratory disease in young calves. BRSV …

Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes

R Janssen, L Bont, CLE Siezen… - Journal of Infectious …, 2007 - academic.oup.com
Background. Respiratory syncytial virus (RSV) is a common cause of severe lower
respiratory tract infection in infants. Only a proportion of children infected with RSV require …

The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism …

Z Sun, Z Chen, SR Lawson, Y Fang - Journal of virology, 2010 - Am Soc Microbiol
Porcine reproductive and respiratory syndrome (PRRS) virus nonstructural protein 2 (nsp2)
contains a cysteine protease domain at its N terminus, which belongs to the ovarian tumor …

Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I

Z Ling, KC Tran, MN Teng - Journal of virology, 2009 - Am Soc Microbiol
ABSTRACT A wide variety of RNA viruses have been shown to produce proteins that inhibit
interferon (IFN) production and signaling. For human respiratory syncytial virus (RSV), the …

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

J Elliott, OT Lynch, Y Suessmuth, P Qian… - Journal of …, 2007 - Am Soc Microbiol
Respiratory syncytial virus (RSV) infection causes bronchiolitis and pneumonia in infants.
RSV has a linear single-stranded RNA genome encoding 11 proteins, 2 of which are …

Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-κB-dependent, interferon-independent mechanism and facilitate virus …

V Bitko, O Shulyayeva, B Mazumder… - Journal of …, 2007 - Am Soc Microbiol
The two nonstructural (NS) proteins NS1 and NS2 of respiratory syncytial virus (RSV) are
abundantly expressed in the infected cell but are not packaged in mature progeny virions …