The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

An increasing number of studies demonstrate the potential use of cell-free DNA (cfDNA) as a
surrogate marker for multiple indications in cancer, including diagnosis, prognosis, and …

Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young …

Explosive advances in next‐generation sequencer (NGS) and computational analyses have
enabled exploration of somatic protein‐altered mutations in most cancer types, with coding …

Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part
of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer …

DNA transfer from cytoplasmic organelles to the cell nucleus is a legacy of the
endosymbiotic event—the majority of nuclear-mitochondrial segments (NUMTs) are thought …

Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Next-generation sequencing technology has enabled the comprehensive detection of
genomic alterations in human somatic cells, including point mutations, chromosomal …