Umbilical cord blood collected from the postpartum placenta and cord is a rich source of
hematopoietic stem cells (HSCs) and is an alternative to bone marrow transplantation. In this …

Considerable evidence from both human and animal studies indicates that CD4+ cells are
the predominant cell type involved in the regulation of airway inflammation through the …

Mast cells, due to their ability to produce a large panel of mediators and cytokines,
participate in a variety of processes in adaptive and innate immunity. Herein we report that in …

All types of thymic cells are able to produce cytokines either spontaneously or after
stimulation. The main producers of cytokines in the thymus are thymic epithelial cells (TEC) …

The initial idea of a distinct group of T-cells responsible for suppressing immune responses
was first postulated half a century ago. However, it is only in the last three decades that we …

Summary Interleukin (IL)-9 is a 28-30 kDa monomeric glycosylated polypeptide belonging to
the IL-7/IL-9 family of proteins that bind to a composite receptor consisting of the private …

Recently, two SCID (severe combined immunodeficiency disease) patients with greatly
diminished T cells but normal or increased numbers of B and NK cells (T–B+ NK+ SCID) …

Abstract Type 1 diabetes (T1D) and celiac disease (CeD) are common autoimmune
diseases in children where the pathophysiology is not fully characterized. The autoimmune …

Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor
Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and …

The aberrant fusion protein NPM-ALK plays an important pathogenetic role in ALK+
anaplastic large-cell lymphoma (ALCL). We previously demonstrated that Jak3 potentiates …