[HTML][HTML] Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

G Tang, S Li, C Zhang, H Chen, N Wang… - … Pharmaceutica Sinica B, 2021 - Elsevier
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes
mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious …

[HTML][HTML] Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects

X Li, Y Zhang, X Xing, M Li, Y Liu, A Xu… - Biomedicine & …, 2023 - Elsevier
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant
challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it …

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification …

BH Liu, Y Tu, GX Ni, J Yan, L Yue, ZL Li… - Frontiers in …, 2021 - frontiersin.org
Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted
from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in …

[HTML][HTML] Taraxasterol alleviates aflatoxin B1-induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy

R Sang, B Ge, H Li, H Zhou, K Yan, W Wang… - Ecotoxicology and …, 2023 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) is the most dangerous and abundant mycotoxin, which is toxic
to almost all animals, and poultry is more sensitive to AFB 1 toxicity. Ingesting AFB 1 …

[HTML][HTML] Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling …

X Wang, L Jiang, X Liu, Y Huang, A Wang, H Zeng… - Phytomedicine, 2022 - Elsevier
Ethnopharmacological relevance Paeoniflorin (PF) was found to exhibit renal protection
from diabetic kidney disease (DKD) in previous trials, but its specific mechanism remains to …

Dysregulated autophagy: a key player in the pathophysiology of type 2 diabetes and its complications

A Sehrawat, J Mishra, SS Mastana, U Navik… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Autophagy is essential in regulating the turnover of macromolecules via removing damaged
organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and …

Astragalus membranaceus and Salvia miltiorrhiza ameliorate diabetic kidney disease via the “gut-kidney axis”

Z Shen, T Cui, Y Liu, S Wu, C Han, J Li - Phytomedicine, 2023 - Elsevier
Abstract Background The combination of Astragalus membranaceus and Salvia miltiorrhiza
(AS) is an effective prescription for treating diabetic kidney disease (DKD) in traditional …

Effective dose/duration of natural flavonoid quercetin for treatment of diabetic nephropathy: A systematic review and meta-analysis of rodent data

Z Li, H Deng, X Guo, S Yan, C Lu, Z Zhao, X Feng, Q Li… - Phytomedicine, 2022 - Elsevier
Background Given the challenges on diabetic nephropathy (DN) treatment, research has
been carried out progressively focusing on dietary nutrition and natural products as a novel …

Pharmacological potential of Astragali Radix for the treatment of kidney diseases

Y Shi, X Shi, M Zhao, S Ma, Y Zhang - Phytomedicine, 2024 - Elsevier
Background With the increasing prevalence of hypertension, diabetes, and obesity, the
incidence of kidney diseases is also increasing, resulting in a serious public burden …

Inhibition of PI3K/AKT/mTOR signalling pathway activates autophagy and suppresses peritoneal fibrosis in the process of peritoneal dialysis

M Jia, H Qiu, L Lin, S Zhang, D Li, D Jin - Frontiers in physiology, 2022 - frontiersin.org
Peritoneal dialysis (PD) is an important part of replacement therapy for kidney failure.
However, long-term PD treatment can cause peritoneal fibrosis. Autophagy may be involved …