Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

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Traditionally, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has
been explained on the basis of their inhibition of the enzymes that synthesise …

Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons,
and thereby produces severe pain. A nonselective cation channel activated by capsaicin …

The endocrine, metabolic and inflammatory responses to injury and infection are composed
of a variety of physiological changes often grouped together and called the surgical stress …

1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy
human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused …

There is compelling evidence linking bradykinin (BK) with the pathophysiological processes
that accompany tissue damage and inflammation, especially the production of pare and …

Intrathecal administration of glycine (strychnine) or GABA (bicuculline) but not opioid
(naloxone), adrenergic (phentolamine) or serotonin (methysergide) receptor antagonists …

Not only are some clinical conditions experienced as more painful than others, but the
variability in pain ratings of patients with the same disease or trauma is enormous. Available …