Hearing loss: The final frontier of pharmacology
AC Foster, BE Jacques, F Piu - Pharmacology research & …, 2022 - Wiley Online Library
Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs
for the treatment of hearing loss. Research over the past two decades has led to a vastly …
for the treatment of hearing loss. Research over the past two decades has led to a vastly …
The genomics of auditory function and disease
S Taiber, K Gwilliam, R Hertzano… - Annual review of …, 2022 - annualreviews.org
Current estimates suggest that nearly half a billion people worldwide are affected by hearing
loss. Because of the major psychological, social, economic, and health ramifications …
loss. Because of the major psychological, social, economic, and health ramifications …
Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration
Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature …
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
Expression of Atoh1, Gfi1, and Pou4f3 in the mature cochlea reprograms nonsensory cells into hair cells
Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate;
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …
Recent advances in molecular studies on cochlear development and regeneration
Y Sun, Z Liu - Current Opinion in Neurobiology, 2023 - Elsevier
The auditory organ cochlea harbors two types of sound receptors, inner hair cells (IHCs) and
outer hair cells (OHCs), which are innervated by spiral (auditory) ganglion neurons (SGNs) …
outer hair cells (OHCs), which are innervated by spiral (auditory) ganglion neurons (SGNs) …
Cochlear health and cochlear-implant function
KC Schvartz-Leyzac, DJ Colesa, DL Swiderski… - Journal of the …, 2023 - Springer
The cochlear implant (CI) is widely considered to be one of the most innovative and
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …
Reprogramming cellular identity in vivo
S Leaman, N Marichal, B Berninger - Development, 2022 - journals.biologists.com
Cellular identity is established through complex layers of genetic regulation, forged over a
developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these …
developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these …
Transcription factor reprogramming in the inner ear: turning on cell fate switches to regenerate sensory hair cells
Non-mammalian vertebrates can restore their auditory and vestibular hair cells naturally by
triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a …
triggering the regeneration of adjacent supporting cells. The transcription factor ATOH1 is a …
GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor
GFI1 is a zinc finger transcription factor that is necessary for the differentiation and survival of
hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of …
hair cells in the cochlea. Deletion of Gfi1 in mice significantly reduces the expression of …