The regulation of muscle contraction is a critical function in the cardiovascular system, and
abnormalities may be life-threatening or cause illness. The common basic mechanism in …

Simple Summary Recently, a group of genes called “Hippo” has been discovered that is
critical for the development and progression of a wide types of cancers. Therefore …

Background The gastrointestinal motility is affected by gut microbiota and the relationship
between them has become a hot topic. However, mechanisms of microbiota in regulating …

The gut microbiota is involved in various physiological functions, and disturbances in the
host-microbiome have been proven to contribute to the dysfunction of gut; however, whether …

Background Ovarian cancer is one of the most common and malignant cancers, partly due to
its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor …

The axon initial segment (AIS) is the site of action potential generation and a locus of activity-
dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a …

Myosin light chain phosphatase with its regulatory subunit, myosin phosphatase target
subunit 1 (MYPT1) modulates Ca 2+-dependent phosphorylation of myosin light chain by …

The intestinal barrier defends against pathogenic microorganism and microbial toxin. Its
function is regulated by tight junction permeability and epithelial cell integrity, and disruption …

Abstract Polo-like kinase 1 (PLK1), an essential regulator of cell division, is currently
undergoing clinical evaluation as a target for cancer therapy. We report an unexpected …

Obesity is one of the most serious public health problems. Peroxisome proliferator-activated
receptor γ (PPARγ) plays the master role in adipocyte differentiation for obesity …