Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …

Abstract Machado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3
(SCA3), represents the most common form of SCA worldwide. MJD is an autosomal …

Spinocerebellar ataxia type-3 (SCA3) is among the most common dominantly inherited
ataxias, and is one of nine devastating human neurodegenerative diseases caused by the …

The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to
modulate function and is a key step in protein degradation, epigenetic modification and …

Spinocerebellar ataxia type 3 is a neurodegenerative disease caused by expansion of a
polyglutamine domain in the protein ataxin-3 (ATXN3). Physiological functions of ATXN3 …

Machado–Joseph disease is the most frequently found dominantly-inherited cerebellar
ataxia. Over-repetition of a CAG trinucleotide in the MJD1 gene translates into a …

Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …

Machado–Joseph disease or spinocerebellar ataxia type 3 (MJD/SCA3) is a fatal, autosomal
dominant disorder caused by a cytosine-adenine-guanine expansion in the coding region of …

The history of polyglutamine diseases dates back approximately 20 years to the discovery of
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …