Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Alzheimer’s disease as a chronic maladaptive polyamine stress response - PMC Back to Top
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Simple Summary With the increase in the geriatric population worldwide, the promotion of
healthy aging arose as a key issue and, hence, the scientific community dedicates huge …

Mitochondria are the powerhouses of the cell. They produce a significant amount of the
energy we need to grow, survive and reproduce. The same system that generates energy in …

Pulmonary fibrosis (PF) is an epithelial/fibroblastic crosstalk disorder of the lungs with highly
complex etiopathogenesis. Limited treatment possibilities are responsible for poor prognosis …

Mechanical perturbation triggers activation of resident myogenic stem cells to enter the cell
cycle through a cascade of events including hepatocyte growth factor (HGF) release from its …

Bone metastatic prostate cancer (BM-PCa) remains one of the most difficult cancers to treat
due to the complex interactions of cancer and stromal cells. We previously showed that bone …

Endothelial dysfunction (EnD) occurs with aging and endothelial nitric oxide (NO) production
by NO synthase (NOS) can be impaired. Low NO levels have been linked to increased …

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …

Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive
capacity of the organism, as a result of which the body becomes less adaptable to stressful …