Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

The structure and organization of a species genome at a karyotypic level, and in interphase
nuclei, have broad functional significance. Although regular sized chromosomes are studied …

Genomes undergo changes in organization as a result of gene duplications, chromosomal
rearrangements and local mutations, among other mechanisms. In contrast to prokaryotes …

Asexual reproduction in animals, though rare, is the main or exclusive mode of reproduction
in some long-lived lineages. The longevity of asexual clades may be correlated with the …

Our understanding of genomic reorganization, the mechanics of genomic transmission to
offspring during germ line formation, and how these structural changes contribute to the …

Genomic rearrangements are a major source of evolutionary divergence in eukaryotic
genomes, a cause of genetic diseases and a hallmark of tumor cell progression, yet the …

Current approaches detect conserved genomic order either at chromosomal (macrosynteny)
or at subchromosomal scales (microsynteny). The latter generally requires collinearity and …

We use graph theory to analyze chromatin interaction (Hi-C) data in the human genome. We
show that a key functional feature of the genome—“master” replication origins—corresponds …

Recent analysis of genome-wide epigenetic modification data, mean replication timing
(MRT) profiles and chromosome conformation data in mammals have provided increasing …