As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Intracellular sensing of lipopolysaccharide (LPS) by murine caspase-11 or human caspase-
4 initiates a protease cascade, termed the non-canonical inflammasome, that results in …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1
and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from …

Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require
cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and …

Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the
health of millions of people in the United States and worldwide. Currently, there are no …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …