Lung infections associated with cystic fibrosis
While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is
now recognized as a single disease whose diverse symptoms stem from the wide tissue …
now recognized as a single disease whose diverse symptoms stem from the wide tissue …
Structure, gating, and regulation of the CFTR anion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …
Molecular structure of the human CFTR ion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
Structure and function of the CFTR chloride channel
DN Sheppard, MJ Welsh - Physiological reviews, 1999 - journals.physiology.org
Sheppard, David N., and Michael J. Welsh. Structure and Function of the CFTR Chloride
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …
Channel. Physiol. Rev. 79, Suppl.: S23–S45, 1999.—The cystic fibrosis transmembrane …
The ABC protein turned chloride channel whose failure causes cystic fibrosis
CFTR chloride channels are encoded by the gene mutated in patients with cystic fibrosis.
These channels belong to the superfamily of ABC transporter ATPases. ATP-driven …
These channels belong to the superfamily of ABC transporter ATPases. ATP-driven …
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
K Kunzelmann, M Mall - Physiological reviews, 2002 - journals.physiology.org
The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …
Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects
KE Barrett, SJ Keely - Annual review of physiology, 2000 - annualreviews.org
▪ Abstract Chloride secretion is the major determinant of mucosal hydration thoughout the
gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion …
gastrointestinal tract, and chloride transport is also pivotal in the regulation of fluid secretion …
Physiological substrates of cAMP-dependent protein kinase
JB Shabb - Chemical reviews, 2001 - ACS Publications
The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …
Structure of nucleotide‐binding domain 1 of the cystic fibrosis transmembrane conductance regulator
HA Lewis, SG Buchanan, SK Burley, K Conners… - The EMBO …, 2004 - embopress.org
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP‐binding cassette
(ABC) transporter that functions as a chloride channel. Nucleotide‐binding domain 1 …
(ABC) transporter that functions as a chloride channel. Nucleotide‐binding domain 1 …
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis
DC Gadsby, AC Nairn - Physiological reviews, 1999 - journals.physiology.org
Gadsby, David C., and Angus C. Nairn. Control of CTFR Channel Gating by Phosphorylation
and Nucleotide Hydrolysis. Physiol. Rev. 79, Suppl.: S77–S107, 1999.—The cystic fibrosis …
and Nucleotide Hydrolysis. Physiol. Rev. 79, Suppl.: S77–S107, 1999.—The cystic fibrosis …