One loop to rule them all: the ping-pong cycle and piRNA-guided silencing
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …
the genetic information of animal germ cells from the deleterious effects of molecular …
From guide to target: molecular insights into eukaryotic RNA-interference machinery
JJ Ipsaro, L Joshua-Tor - Nature structural & molecular biology, 2015 - nature.com
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent,
specific and ubiquitous means of gene regulation. Through a number of pathways that are …
specific and ubiquitous means of gene regulation. Through a number of pathways that are …
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
A Le Thomas, AK Rogers, A Webster… - Genes & …, 2013 - genesdev.cshlp.org
In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs)
provide a defense system against the expression of transposable elements. In the …
provide a defense system against the expression of transposable elements. In the …
The rhino-deadlock-cutoff complex licenses noncanonical transcription of dual-strand piRNA clusters in Drosophila
Argonaute proteins of the PIWI clade are central to transposon silencing in animal gonads.
Their target specificity is defined by 23–30 nt PIWI interacting RNAs (piRNAs), which mostly …
Their target specificity is defined by 23–30 nt PIWI interacting RNAs (piRNAs), which mostly …
Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing
A Le Thomas, E Stuwe, S Li, J Du… - Genes & …, 2014 - genesdev.cshlp.org
Small noncoding RNAs that associate with Piwi proteins, called piRNAs, serve as guides for
repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the …
repression of diverse transposable elements in germ cells of metazoa. In Drosophila, the …
Bacterial argonaute samples the transcriptome to identify foreign DNA
I Olovnikov, K Chan, R Sachidanandam, DK Newman… - Molecular cell, 2013 - cell.com
Summary Eukaryotic Argonautes bind small RNAs and use them as guides to find
complementary RNA targets and induce gene silencing. Though homologs of eukaryotic …
complementary RNA targets and induce gene silencing. Though homologs of eukaryotic …
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Transposable elements (TEs) contribute to the large amount of repetitive sequences in
mammalian genomes and have been linked to species-specific genome innovations by …
mammalian genomes and have been linked to species-specific genome innovations by …
piRNA Biogenesis in Drosophila melanogaster
The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the
genome integrity of the animal germline from deleterious transposable elements. Targets of …
genome integrity of the animal germline from deleterious transposable elements. Targets of …
Paramutation in Drosophila linked to emergence of a piRNA-producing locus
A De Vanssay, AL Bougé, A Boivin, C Hermant… - Nature, 2012 - nature.com
A paramutation is an epigenetic interaction between two alleles of a locus, through which
one allele induces a heritable modification in the other allele without modifying the DNA …
one allele induces a heritable modification in the other allele without modifying the DNA …
[HTML][HTML] The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing
Summary piRNAs guide an adaptive genome defense system that silences transposons
during germline development. The Drosophila HP1 homolog Rhino is required for germline …
during germline development. The Drosophila HP1 homolog Rhino is required for germline …