The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …

In vitro models of the human liver are important for the following:(1) mitigating the risk of drug-
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …

Various factors, including the phylogenetic distance between laboratory animals and
humans, the discrepancy between current in vitro systems and the human body, and the …

Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban,
withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally …

Artificial and bioartificial liver support systems (LSSs) appear to be safe and effective in the
treatment of acute and acute‑on‑chronic hepatic failure (AHF and AOCHF); however …

Hepatic cell cultures are exploited for different applications in liver disease studies, drug
toxicity testing and bioartificial liver (BAL) devices. Despite the development of various 3D …

Liver transplantation is currently the most efficacious treatment for end-stage liver diseases.
However, one main problem with liver transplantation is the limited number of donor organs …

Tissue engineering combines the principles of materials and cell transplantation to develop
substitute tissues and/or promote endogenous regeneration. The approach was initially …

Bioartificial liver (BAL) system is promising as an alternative treatment for liver failure. We
have developed a bioreactor with stacked sandwich culture plates for the application of BAL …