Insulin receptor (INSR) has been extensively studied in the area of cell proliferation and
energy metabolism. Impaired INSR activities lead to insulin resistance, the key factor in the …

This review aimed to focus on the recent progress of the understanding of the role of
phosphatidylinositol 3-kinase (PI3K) in polycystic ovary syndrome (PCOS). In recent years, it …

Scope Fructose consumption can induce insulin resistance and metabolic syndrome, which
are associated with glomerular podocyte dysfunction and proteinuria. This study …

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/metabolic
disorder characterized by hyperandrogenemia and in most cases, by hyperinsulinemia in …

Adipocytes exposed to high glucose concentrations exhibit impaired metabolic function,
including an increase of oxidative and proinflammatory factors that might favor the …

Polycystic ovary syndrome (PCOS) may present important comorbidities, such as
cardiovascular and metabolic diseases, which are often preceded by changes in cardiac …

Polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder associated with
insulin resistance. Insulin exerts its metabolic function by activating the PI3K/Akt pathway …

Introduction The incidence of infertility is significantly higher in women with diseases linked
to impaired glucose homeostasis, such as insulin resistance. Defective glucose metabolism …

Context: In a previous microarray analysis, GRB2-associated binding protein 1 (GAB1), a
docking protein closely related to the insulin receptor substrate, was down-regulated in …

Antecedentes: El síndrome de ovario poliquístico (SOP), patología endocrinometabólica,
afecta alrededor del 15% de mujeres en edad fértil, afectando principalmente la función del …