The neurotransmitter glutamate activates several classes of metabotropic receptor and three
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …

Progression of brain ageing is influenced by a complex interaction of genetic and
environmental factors. Analysis of genetically modified animals with uniform genetic …

In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …

Acetlylcholine (ACh) in the central nervous system is critical for a multitude of functions.
Here, we concentrate on declarative memory in humans, and its equivalent episodic-like …

Autism spectrum disorders (ASD) are defined by behavioral deficits in social interaction and
communication, repetitive stereotyped behaviors, and restricted interests/cognitive rigidity …

Memantine is an N-methyl-d-aspartate receptor antagonist that is approved for the treatment
of moderate to severe Alzheimer's disease (AD). In this study, three groups of triple …

Alzheimer's disease (AD) ranks sixth on the Centers for Disease Control and Prevention Top
10 Leading Causes of Death list for 2016, and the Alzheimer's Association attributes 60% to …

Recent advances in the understanding of the pathophysiological mechanisms underlying
Alzheimer's disease have pointed to novel strategies for drug development. Animal models …

Alzheimer's disease is a progressive neurodegenerative disorder characterised by the
gradual onset of dementia. The pathological hallmarks of the disease are β‐amyloid (Aβ) …

The aim of this study was to investigate the effects and the mechanism of diosgenin, a
famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) …