The clinical efficacy and safety of anti-viral agents for non-hospitalized patients with COVID-19: a systematic review and network meta-analysis of randomized …

CC Lai, YH Wang, KH Chen, CH Chen, CY Wang - Viruses, 2022 - mdpi.com
This network meta-analysis compared the clinical efficacy and safety of anti-viral agents for
the prevention of disease progression among non-hospitalized patients with COVID-19 …

[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Y Gupta, OV Savytskyi, M Coban, A Venugopal… - Molecular Aspects of …, 2023 - Elsevier
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper

T Marjot, CS Eberhardt, T Boettler, LS Belli… - Journal of …, 2022 - Elsevier
The COVID-19 pandemic has presented a serious challenge to the hepatology community,
particularly healthcare professionals and patients. While the rapid development of safe and …

Nirmatrelvir–ritonavir compared with other antiviral drugs for the treatment of COVID‐19 patients: A systematic review and meta‐analysis

F Tian, Z Chen, Q Feng - Journal of Medical Virology, 2023 - Wiley Online Library
At present, there are some differences in the research results of nirmatrelvir–ritonavir
compared with other antiviral drugs for the treatment of COVID‐19 patients. We aimed to …

Efficacy and safety of molnupiravir treatment for COVID-19: a systematic review and meta-analysis of randomized controlled trials

F Tian, Q Feng, Z Chen - International Journal of Antimicrobial Agents, 2023 - Elsevier
Introduction There are currently some differences in the research results of molnupiravir.
This study aimed to evaluate the efficacy and safety of molnupiravir in the treatment of …

Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections

SJ Hurwitz, R De, JC LeCher, JA Downs-Bowen… - Viruses, 2024 - mdpi.com
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median
effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical …

Evaluation of oral small molecule drugs for the treatment of COVID-19 patients: a systematic review and network meta-analysis

Z Chen, F Tian - Annals of Medicine, 2023 - Taylor & Francis
Introduction At present, there are some randomized controlled trials (RCTs) of oral small
molecule drugs. The purpose of this study was to evaluate the efficacy and safety of oral …

Favipiravir-based treatment for outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

SH Lan, CC Lai, SP Chang, LC Lu… - Expert Review of …, 2022 - Taylor & Francis
Background This meta-analysis of randomized controlled trials (RCTs) investigated the
clinical efficacy and safety of favipiravir for patients with mild-to-critical COVID-19. Methods …

[HTML][HTML] Small-molecule antivirals treatment for COVID-19: A systematic review and network meta-analysis

B Zheng, Q Zhao, W Yang, P Feng, C Xin, Y Ying… - International Journal of …, 2024 - Elsevier
Objective This study aimed to explore the efficacy and safety of small-molecule antivirals for
treating coronavirus disease 2019 (COVID-19). Methods Seven databases were searched …

Clinical outcomes, virological efficacy and safety of nitazoxanide in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized …

TC Weng, TS Weng, CC Lai, CM Chao… - Expert Review of Anti …, 2022 - Taylor & Francis
Background This study investigated the clinical outcomes, virological efficacy and safety of
nitazoxanide in the treatment of patients with COVID-19. Research design and methods The …