Food-derived peptides, as dietary supplements, have significant effects on promoting brain
health and relieving central nervous system (CNS) diseases. However, the blood–brain …

Most plastics in use today are derived from petrochemical resources, resulting in severe
environmental problems. As fossil resources are depleting, polymers derived from …

Biologics, including proteins and antisense oligonucleotides (ASOs), face significant
challenges when it comes to achieving intracellular delivery within specific organs or cells …

Membrane technology is one of the most sustainable methodologies in industrial
separations due to its low cost, straightforward scale-up with more compact systems, simple …

Thiol-mediated uptake (TMU) is an intriguing enigma in current chemistry and biology. While
the appearance of cell-penetrating activity upon attachment of cascade exchangers (CAXs) …

Thiol-mediated uptake (TMU) is thought to occur through dynamic covalent cascade
exchange networks. Here we show that the cascade accounting for TMU of asparagusic acid …

Since the early 1990s, there has been considerable interest in cell-penetrating peptides
(CPPs) capable of transporting various types of molecules in cells. These CPPs are …

Dynamic‐covalent electrophiles called cascade exchangers (CAXs) can reversibly engage
cell‐surface thiols. Conjugates between CAXs and molecular or even protein‐sized cargos …

Cell‐penetrating peptides (CPPs) have been explored as versatile tools to transport various
molecules into cells. The uptake mechanism of CPPs is still not clearly understood and most …

Thiol-Mediated Uptake (TMU, TIMEUP) Page 1 ERC & SNSF-ERC FuNdEd RESEaRCh
2019–2023 CHIMIA 2024, 78, No. 10 665 *Correspondence: Prof. S. Matile, E-mail: stefan.matile@unige.ch …