Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

P La Rosée, AC Horne, M Hines… - Blood, The Journal …, 2019 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome
induced by aberrantly activated macrophages and cytotoxic T cells. The primary (genetic) …

A comprehensive review on adult onset Still's disease

R Giacomelli, P Ruscitti, Y Shoenfeld - Journal of autoimmunity, 2018 - Elsevier
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology
usually affecting young adults; spiking fever, arthritis and evanescent rash are commonly …

Hemophagocytic lymphohistiocytosis: an update on pathogenesis, diagnosis, and therapy

G Griffin, S Shenoi, GC Hughes - Best Practice & Research Clinical …, 2020 - Elsevier
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Hemophagocytic lymphohistiocytosis

H Al-Samkari, N Berliner - Annual review of pathology …, 2018 - annualreviews.org
Hemophagocytic lymphohistiocytosis is a life-threatening disorder characterized by
unbridled activation of cytotoxic T lymphocytes, natural killer (NK) cells, and macrophages …

[HTML][HTML] Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic

M Soy, P Atagündüz, I Atagündüz, GT Sucak - Rheumatology international, 2021 - Springer
Hemophagocytic syndrome (HPS) or hemophagocytic lymphohistiocytosis (HLH) is an acute
and rapidly progressive systemic inflammatory disorder characterized by cytopenia …

Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment

SJ Carter, RS Tattersall, AV Ramanan - Rheumatology, 2019 - academic.oup.com
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome, which if not
promptly treated, can lead rapidly to critical illness and death. HLH is termed macrophage …

The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage …

B Shakoory, A Geerlinks, M Wilejto, K Kernan… - Annals of the …, 2023 - ard.bmj.com
Objective Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation
syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can …

[HTML][HTML] Adult-onset Still's disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers

P Ruscitti, P Cipriani, F Masedu, D Iacono, F Ciccia… - BMC medicine, 2016 - Springer
Abstract Background Adult-onset Still's disease (AOSD) is rare inflammatory disease of
unknown etiology that usually affects young adults. The more common clinical …

Macrophage activation syndrome in patients affected by adult-onset Still disease: analysis of survival rates and predictive factors in the Gruppo Italiano di Ricerca in …

P Ruscitti, D Iacono, F Ciccia, G Emmi… - The Journal of …, 2018 - jrheum.org
Macrophage Activation Syndrome in Patients Affected by Adult-onset Still Disease: Analysis of
Survival Rates and Predictive Factors in the Gruppo Italiano di Ricerca in Reumatologia …

[HTML][HTML] Pro-inflammatory properties of H-ferritin on human macrophages, ex vivo and in vitro observations

P Ruscitti, P Di Benedetto, O Berardicurti, N Panzera… - Scientific reports, 2020 - nature.com
Ferritin is an iron-binding molecule, which comprises 24 subunits, heavy (FeH) and light
(FeL) subunits, suggested to have a pathogenic role by the 'hyperferritinemic syndrome'. In …