Since the identification of the causative gene in Huntington's disease (HD), a number of
animal models of this disorder have been developed. A frequently asked question is: which …

Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

White matter abnormalities are a nearly universal pathological feature of neurodegenerative
disorders including Huntington disease (HD). A long-held assumption is that this white …

Huntington disease (HD) model mice with heterozygous knock-in (KI) of an expanded CAG
tract in exon 1 of the mouse huntingtin (Htt) gene homolog genetically recapitulate the …

Post-translational modification of proteins by the lipid palmitate is critical for protein
localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl …

Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its
aetiology and early pathological manifestations remain poorly defined. In this study, we …

Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-
modifying therapy currently available. In addition to characteristic motor deficits and atrophy …

Huntington disease (HD) is a genetic neurodegenerative disorder for which there is currently
no cure and no way to stop or even slow the brain changes it causes. In the present study …