The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of
the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining …

A class of recessive lethal zebrafish mutations has been identified in which normal skeletal
muscle differentiation is followed by a tissue-specific degeneration that is reminiscent of the …

The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal
muscle, which lead to a loss of muscle function and are often fatal. While many of the loci …

Zebrafish reproduce in large quantities, grow rapidly, and are transparent early in
development. For these reasons, zebrafish have been used extensively to model vertebrate …

Muscular dystrophies are a group of genetic disorders that specifically affect skeletal muscle
and are characterized by progressive muscle degeneration and weakening. To develop …

[Frontiers in Bioscience 7, d1439-1453, June 1, 2002] 1439 THE ZEBRAFISH AS A MODEL
FOR HUMAN DISEASE William T. Penberthy, Ebr Page 1 [Frontiers in Bioscience 7, d1439-1453 …

Many cases of muscular dystrophy in humans are caused by mutations in members of the
dystrophin associated protein complex (DAPC). Zebrafish are small vertebrates whose …

Mutations in the gene coding for selenoprotein N (SelN), a selenium containing protein of
unknown function, cause different forms of congenital muscular dystrophy in humans. These …

Muscular dystrophies (MD) are a heterogeneous group of genetic disorders that cause
muscle weakness, abnormal contractions and muscle wasting, often leading to premature …