Cellular responses to Cisplatin‐induced DNA damage

A Basu, S Krishnamurthy - Journal of nucleic acids, 2010 - Wiley Online Library
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Beyond chemotherapy: targeted therapies in ovarian cancer

TA Yap, CP Carden, SB Kaye - Nature Reviews Cancer, 2009 - nature.com
Ovarian cancer is the leading cause of death from gynaecological malignancies in the
Western world. Despite the evolution of surgical techniques and meticulously designed …

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

L Zhang, Q Zhou, Q Qiu, L Hou, M Wu, J Li, X Li, B Lu… - Molecular Cancer, 2019 - Springer
Background Emerging evidence has shown that circular RNAs (circRNAs) play essential
roles in cancer biology and are potential biomarkers and targets for cancer therapy …

Chemoresistance and targeted therapies in ovarian and endometrial cancers

K Brasseur, N Gévry, E Asselin - Oncotarget, 2016 - pmc.ncbi.nlm.nih.gov
Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

[HTML][HTML] Critical protein GAPDH and its regulatory mechanisms in cancer cells

JY Zhang, F Zhang, CQ Hong, AE Giuliano… - Cancer biology & …, 2015 - ncbi.nlm.nih.gov
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …

PD-1/PD-L1 and DNA damage response in cancer

M Kciuk, D Kołat, Ż Kałuzińska-Kołat, M Gawrysiak… - Cells, 2023 - mdpi.com
The application of immunotherapy for cancer treatment is rapidly becoming more
widespread. Immunotherapeutic agents are frequently combined with various types of …

[HTML][HTML] Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4-and HIF-1α-mediated regulation of apoptosis and autophagy

X Zhang, Z Qi, H Yin, G Yang - Theranostics, 2019 - ncbi.nlm.nih.gov
The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the
detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 …

Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK

NM Weir, K Selvendiran, VK Kutala, L Tong… - Cancer biology & …, 2007 - Taylor & Francis
Curcumin, a major active component of turmeric, is known to induce apoptosis in several
types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the …

Substrate stiffness modulates the growth, phenotype, and chemoresistance of ovarian cancer cells

Y Fan, Q Sun, X Li, J Feng, Z Ao, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Mechanical factors in the tumor microenvironment play an important role in response to a
variety of cellular activities in cancer cells. Here, we utilized polyacrylamide hydrogels with …

[PDF][PDF] Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis

X Yang, Y Zhou, S Peng, L Wu, HY Lin, S Wang… - …, 2012 - researchgate.net
REPRODUCTION Page 1 REPRODUCTION RESEARCH Differentially expressed plasma
microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a …