ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

The hepatic organic anion transporting polypeptides (OATPs) influence the
pharmacokinetics of several drug classes and are involved in many clinical drug–drug …

Breast cancer resistance protein (BCRP)/ATP-binding cassette subfamily G member 2
(ABCG2) is an ATP-binding cassette (ABC) transporter identified as a molecular cause of …

Human ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily and
is known to contribute to multidrug resistance (MDR) in cancer chemotherapy. Among ABC …

ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the
subject of intense study since its discovery a decade ago. With high normal tissue …

In the recent years, eight tyrosine kinase inhibitors (TKIs) have been approved for cancer
treatment and numerous are under investigation. These drugs are rationally designed to …

Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …