Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

Introduction: Adjuvants are used to improve vaccine immunogenicity and efficacy by
enhancing antigen presentation to antigen-specific immune cells with the aim to confer long …

The concept of stimulating the body's immune response is the basis underlying vaccination.
Vaccines act by initiating the innate immune response and activating antigen presenting …

While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

Background Neurofibrillary pathology composed of tau protein is a main correlate of
cognitive impairment in patients with Alzheimer's disease. Immunotherapy targeting …

Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …

The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Introduction We have identified structural determinants on tau protein that are essential for
pathological tau–tau interaction in Alzheimer's disease (AD). These regulatory domains …

Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …