Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level

I Kyriakou, D Sakata, HN Tran, Y Perrot, WG Shin… - Cancers, 2021 - mdpi.com
Simple Summary A brief description of the methodologies to simulate ionizing radiation
transport in biologically relevant matter is presented. Emphasis is given to the physical …

Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping

W Friedland, E Schmitt, P Kundrát, M Dingfelder… - Scientific reports, 2017 - nature.com
Track structures and resulting DNA damage in human cells have been simulated for
hydrogen, helium, carbon, nitrogen, oxygen and neon ions with 0.25–256 MeV/u energy …

Electronic excitation response of DNA to high-energy proton radiation in water

C Shepard, DC Yost, Y Kanai - Physical Review Letters, 2023 - APS
The lack of molecular-level understanding for the electronic excitation response of DNA to
charged particle radiation, such as high-energy protons, remains a fundamental scientific …

Mechanistic DNA damage simulations in Geant4-DNA Part 2: Electron and proton damage in a bacterial cell

N Lampe, M Karamitros, V Breton, JMC Brown… - Physica Medica, 2018 - Elsevier
We extended a generic Geant4 application for mechanistic DNA damage simulations to an
Escherichia coli cell geometry, finding electron damage yields and proton damage yields …

Non-DSB clustered DNA lesions. Does theory colocalize with the experiment?

Z Nikitaki, V Nikolov, IV Mavragani, I Plante… - Radiation Physics and …, 2016 - Elsevier
Ionizing radiation results in various kinds of DNA lesions such as double strand breaks
(DSBs) and other non-DSB base lesions. These lesions may be formed in close proximity …

Multiscale approach to the physics of radiation damage with ions

E Surdutovich, AV Solov'yov - The European Physical Journal D, 2014 - Springer
The multiscale approach to the assessment of biodamage resulting upon irradiation of
biological media with ions is reviewed, explained and compared to other approaches. The …

Monte Carlo electron track structure calculations in liquid water using a new model dielectric response function

D Emfietzoglou, G Papamichael… - Radiation …, 2017 - meridian.allenpress.com
Monte Carlo track structure codes provide valuable information for understanding radiation
effects down to the DNA level, where experimental measurements are most difficult or …

Perspectives in radiation biophysics: from radiation track structure simulation to mechanistic models of DNA damage and repair

H Nikjoo, R Taleei, T Liamsuwan, D Liljequist… - Radiation Physics and …, 2016 - Elsevier
In radiation targeted therapy and genetic risk estimation of low dose radiation protection
there is a crucial need for full description of DNA damage response and repair (DDR) …

Electronic excitation dynamics in DNA under proton and α-particle irradiation

DC Yost, Y Kanai - Journal of the American Chemical Society, 2019 - ACS Publications
Electronic excitations are produced when matter is exposed to ion irradiation comprising
highly energetic ions. These electronic stopping excitations are responsible for ion beam …

Biodamage via shock waves initiated by irradiation with ions

E Surdutovich, AV Yakubovich, AV Solov'yov - Scientific reports, 2013 - nature.com
Radiation damage following the ionising radiation of tissue has different scenarios and
mechanisms depending on the projectiles or radiation modality. We investigate the radiation …