The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Post-translational modification (PTM) of antigens provides an additional source of
specificities targeted by immune responses to tumors or pathogens, but identifying antigen …

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

The aim of the present study was to clarify the activation of ferroptosis in different breast
cancer cells by sulfasalazine (SAS) and to explore the relationship between the estrogen …

Identification of targeted therapies for TNBC is an urgent medical need. Using a drug
combination screen reliant on synthetic lethal interactions, we identified clinically relevant …

Metabolic plasticity enables cancer cells to switch their metabolism phenotypes between
glycolysis and oxidative phosphorylation (OXPHOS) during tumorigenesis and metastasis …

Resistance to chemotherapeutic agents remains a major challenge in the fierce battle
against cancer. Cancer stem cells (CSCs) are a small population of cells in tumors that …

Breast cancer (BC) is a serious worldwide disease that threatens women's health.
Particularly, the morbidity of triple-negative breast cancer (TNBC) is higher than that of other …

Basal-like breast cancer (BLBC) is the most aggressive subtype of breast tumors with poor
prognosis and limited molecular-targeted therapy options. We show that BLBC cells have a …