Membrane proteins are involved in numerous vital biological processes, including transport,
signal transduction and the enzymes in a variety of metabolic pathways. Integral membrane …

Atherosclerosis is a major contributor to the onset and progression of cardiovascular
disease (CVD). Cholesterol‐loaded foam cells play a pivotal role in forming atherosclerotic …

BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …

In the study of membrane proteins and antimicrobial peptides, nanodiscs have emerged as
a valuable membrane mimetic to solubilze these molecules in a lipid bilayer. We present the …

Summary The Apolipoprotein E gene (APOE) is of great interest due to its role as a risk
factor for late-onset Alzheimer's disease. ApoE is secreted by astrocytes in the central …

Supramolecular protein assemblies have been used as intelligent drug delivery systems that
can encapsulate drugs and transport them to specific tissues or cells. However, the known …

Human high-density lipoproteins (HDLs) are a complex mixture of structurally related
nanoparticles that perform distinct physiological functions. We previously showed that …

Apolipoprotein AI (apoA-I) is cross-linked and dysfunctional in human atheroma. Although
multiple mechanisms of apoA-I cross-linking have been demonstrated in vitro, the in vivo …

Obesity has achieved epidemic status in the United States, resulting in an increase in type 2
diabetes mellitus, dyslipidemia, and cardiovascular disease. Numerous studies have shown …

Severe dengue infections are characterized by endothelial dysfunction shown to be
associated with the secreted nonstructural protein 1 (sNS1), making it an attractive vaccine …