Targeting mechanisms of Pseudomonas aeruginosa pathogenesis

E Kipnis, T Sawa, J Wiener-Kronish - Medecine et maladies infectieuses, 2006 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen responsible for ventilator-acquired
pneumonia, acute lower respiratory tract infections in immunocompromised patients and …

Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity

GB Pier - International journal of medical microbiology, 2007 - Elsevier
Pseudomonas aeruginosa is one of the most important bacterial pathogens encountered by
immunocompromised hosts and patients with cystic fibrosis (CF), and the lipopolysaccharide …

Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Vaccines and immunotherapy against Pseudomonas aeruginosa

G Döring, GB Pier - Vaccine, 2008 - Elsevier
A number of different vaccines and several monoclonal antibodies have been developed in
the last decades for active and passive vaccination against the Gram-negative opportunistic …

Vaccines for Pseudomonas aeruginosa: a long and winding road

GP Priebe, JB Goldberg - Expert review of vaccines, 2014 - Taylor & Francis
Despite the recognition of Pseudomonas aeruginosa as an opportunistic pathogen, no
vaccine against this bacteria has come to market. This review describes the current state-of …

Th17-stimulating Protein Vaccines Confer Protection against Pseudomonas aeruginosa Pneumonia

W Wu, J Huang, B Duan, DC Traficante… - American journal of …, 2012 - atsjournals.org
Rationale: New vaccine approaches are needed for Pseudomonas aeruginosa, which
continues to be a major cause of serious pulmonary infections. Although Th17 cells can …

Recent developments for Pseudomonas vaccines

A Sharma, A Krause, S Worgall - Human vaccines, 2011 - Taylor & Francis
Infections with Pseudomonas aeruginosa are a major health problem for immune-
compromised patients and individuals with cystic fibrosis. A vaccine against P. aeruginosa …

Th17 cytokines and vaccine-induced immunity

Y Lin, SR Slight, SA Khader - Seminars in immunopathology, 2010 - Springer
Abstract T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the
effector molecules IL-17, IL-17F, IL-21, and IL-22. Although the role of Th17 cells in primary …

Generation of a highly attenuated strain of Pseudomonas aeruginosa for commercial production of alginate

ME Valentine, BD Kirby, TR Withers… - Microbial …, 2020 - Wiley Online Library
Alginate is an important polysaccharide that is commonly used as a gelling agent in foods,
cosmetics and healthcare products. Currently, all alginate used commercially is extracted …

IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa

GP Priebe, RL Walsh, TA Cederroth… - The Journal of …, 2008 - journals.aai.org
In a murine model of acute fatal pneumonia, we previously showed that nasal immunization
with a live-attenuated aroA deletant of Pseudomonas aeruginosa strain PAO1 elicited LPS …