Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …

Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been …

Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …

Background A multidrug-resistant co-lineage of Plasmodium falciparum malaria, named
KEL1/PLA1, spread across Cambodia in 2008–13, causing high rates of treatment failure …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

Artemisinin combination therapies (ACTs) are highly effective at treating uncomplicated
Plasmodium falciparum malaria, but the emergence of the new pfkelch13 R561H mutation in …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

The growing prevalence of deadly microbes with resistance to previously life-saving drug
therapies is a dire threat to human health. Detection of low abundance pathogen sequences …

Antimalarial drug resistance has historically arisen through convergent de novo mutations in
Plasmodium falciparum parasite populations in Southeast Asia and South America. For the …