Pioneer factors are a group of transcription factors with important roles in gene regulation
during development. Their unique ability to bind to compacted chromatin, promoting its …

Many chromatin features play critical roles in regulating gene expression. A complete
understanding of gene regulation will require the mapping of specific chromatin features in …

Abstract We recently introduced Cleavage Under Targets & Tagmentation (CUT&Tag), an
epigenomic profiling strategy in which antibodies are bound to chromatin proteins in situ in …

Cleavage under targets and release using nuclease (CUT&RUN) is an epigenomic profiling
strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases …

Previously, we described a novel alternative to chromatin immunoprecipitation, CUT&RUN,
in which unfixed permeabilized cells are incubated with antibody, followed by binding of a …

We describe Cleavage Under Targets and Release Using Nuclease (CUT&RUN), a
chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal …

Plants are responsive to temperature, and some species can distinguish differences of 1° C.
In Arabidopsis, warmer temperature accelerates flowering and increases elongation growth …

Primary liver cancer represents a major health problem. It comprises hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …

If unifying principles could be revealed for how the same genome encodes different
eukaryotic cells and for how genetic variability and environmental input are integrated to …

Mutations that attenuate homologous recombination (HR)-mediated repair promote
tumorigenesis and sensitize cells to chemotherapeutics that cause replication fork collapse …