Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains.
Developing improved vaccines that elicit broader immunity remains a public health priority …

Influenza virus infection is an ongoing health and economic burden causing epidemics with
pandemic potential, affecting 5–30% of the global population annually, and is responsible …

Influenza virus is the pathogen of influenza (flu) and millions of people suffer from the
infection worldwide, posing a significant health risk. The current influenza vaccines induce …

Background Resident memory T cells have emerged as key players in the immune response
generated against a number of pathogens. Their ability to take residence in non-lymphoid …

Despite seasonal influenza vaccines having been routinely used for many decades,
influenza A virus continues to pose a global threat to humans, causing high morbidity and …

There is increasing interest recently in developing intranasal vaccines against respiratory
tract infections. The antibody response is critical for vaccine-induced protection, and T …

Seasonal and pandemic influenza outbreaks present severe health and economic burdens.
To overcome limitations on influenza vaccines' availability and effectiveness, researchers …

Rationale: Needle-free intranasal vaccines offer major potential advantages, especially
against pathogens entering via mucosal surfaces. As yet, there is no effective vaccine …

Background Increasing evidence supports a critical role of CD8+ T-cell immunity against
influenza. Activation of mucosal CD8+ T cells, particularly tissue-resident memory T (TRM) …

The parasite Theileria parva is the causative agent of East Coast fever (ECF), one of the
most serious cattle diseases in sub-Saharan Africa, and directly impacts smallholder …