Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

Stimulator of interferon genes (STING) is an adaptor protein in innate immunity against DNA
viruses or bacteria,,,–. STING-mediated immunity could be exploited in the development of …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Resolving the distribution of specific proteins at the nanoscale in the ultrastructural context of
the cell is a major challenge in fluorescence microscopy. We report the discovery of a new …

Protein palmitoylation, in which C16 fatty acid chains are attached to cysteine residues via a
reversible thioester linkage, is one of the most common lipid modifications and plays …

Triacsins are an intriguing class of specialized metabolites possessing a conserved N-
hydroxytriazene moiety not found in any other known natural products. Triacsins are notable …

With a limited number of genes, cells achieve remarkable diversity. This is to a large extent
achieved by chemical posttranslational modifications of proteins. Amongst these are the lipid …

The Golgi complex is essential for the processing, sorting, and trafficking of newly
synthesized proteins and lipids. Golgi turnover is regulated to meet different cellular …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the
prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While …