A growing number of evidences from clinical and preclinical studies have shown that
dysregulation of microRNA (miRNA) function contributes to the progression of cancer and …

Oligonucleotides (OGNs) are relatively new modalities that offer unique opportunities to
expand the therapeutic targets. Reliable and high-throughput bioanalytical methods are …

We performed a systematic study of thirteen alkylamines used as ion-pairing reagents for ion-
pair reversed-phase liquid chromatography (IP RP LC) separations of oligonucleotides on a …

The choice of alternative materials over stainless steel hardware in the construction of liquid
chromatography systems has unveiled the degree to which nonspecific adsorption impacts …

Quantitative bioanalysis in plasma and tissues samples is required to study the
pharmacokinetic and pharmacodynamic properties of antisense oligonucleotides (ASOs). To …

Abstract Background: Antisense oligonucleotide (ASO), an emerging modality in drug
research and development, demands accurate and sensitive bioanalysis to understand its …

Therapeutic oligonucleotides, such as antisense oligonucleotide (ASO) and small interfering
RNA (siRNA), are a new class of therapeutics rapidly growing in drug discovery and …

Oligonucleotides have many important applications, including as primers in polymerase
chain reactions and probes for DNA sequencing. They are proposed as a diagnostic and …

Nonspecific adsorption has been a consistent challenge in the analysis of oligonucleotides.
Nonspecific adsorption is a result of interactions between charged acidic analytes and …

Background Autoimmune diseases (AD) are severe pathophysiological ailments that are
stimulated by an exaggerated immunogenic response towards self‐antigens, which can …