In the last two decades, numerous in vitro studies demonstrated that insulin receptors and
theirs downstream pathways are widely distributed throughout the brain. This evidence has …

Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Aging increases the susceptibility to a diverse set of diseases and disorders, including
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …

Aging is characterized by a progressive loss of brain volume at an estimated rate of 5% per
decade after age 40. While these morphometric changes, especially those affecting gray …

This study aimed to investigate the effect of circ_0000950/miR-103 network on regulating
neuron apoptosis, neurite outgrowth and inflammation in Alzheimer's disease (AD). Cellular …

A growing number of clinical and epidemiological studies support the hypothesis of a tight
correlation between type 2 diabetes mellitus (T2DM) and the development risk of …

Brain aging is a natural process characterized by cognitive decline and memory loss. This
impairment is related to mitochondrial dysfunction and has recently been linked to the …

Neuroinflammation is one of the core pathological features of Alzheimer's disease (AD) as
both amyloid β (Aβ) and tau monomers and oligomers can trigger the long-term pro …

Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …