Lipid-based carriers represent the most widely used alternative to viral vectors for gene
expression and gene silencing purposes. This class of non-viral vectors is particularly …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …

Several researchers have reported the use of cholesterol-based carriers in drug delivery.
The presence of cholesterol in cell membranes and its wide distribution in the body has led …

Cancer remains one of the leading causes of death worldwide despite significant
therapeutic advancements and improved detection methods. Nucleic acid (NA) therapeutics …

Most lipid formulations require cholesterol for successful transfection, but the precise reason
remains to be more clearly understood. Here, we have studied the effect of cholesterol on …

Lignin nanotubes (LNTs) synthesized from the aromatic plant cell wall polymer lignin in a
sacrificial alumina membrane template have as useful features their flexibility, ease of …

Transfection is a process by which oligonucleotides (DNA or RNA) are delivered into living
cells. This allows the synthesis of target proteins as well as their inhibition (gene silencing) …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

We have previously demonstrated that conjugation of small molecule ligands to small
interfering RNAs (siRNAs) and anti-microRNAs results in functional siRNAs and antagomirs …