Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory
mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) …

Antisense transcription, considered until recently as transcriptional noise, is a very common
phenomenon in human and eukaryotic transcriptomes, operating in two ways based on …

Environmental exposures such as toxicants, nutrition and stress have been shown to
promote the epigenetic transgenerational inheritance of disease susceptibility. Endocrine …

Many environmental toxicants have been shown to be associated with the transgenerational
inheritance of increased disease susceptibility. This review describes the generational …

Increasing brown adipose tissue (BAT) thermogenesis in mice and humans improves
metabolic health and understanding BAT function is of interest for novel approaches to …

The current evolutionary biology theory primarily involves genetic alterations and random
DNA sequence mutations to generate the phenotypic variation required for Darwinian …

Long noncoding RNAs (lncRNAs) are emerging as an integral part of the regulatory
information encoded in the genome. lncRNAs possess the unique capability to interact with …

Background Urothelial cancer associated 1 (UCA1) is a long noncoding RNA (lncRNA)
which has gained more attention in recent years due to its aberrant expression in …